Wynona, a 62 year-old female, comes to the clinic complaining of fatigue and persistent shortness of breath, which becomes worse during exercise. She has a history of respiratory infections and has a chronic cough that is worse in the morning. She worked for 20 years in an automobile manufacturing plant and was laid off 5 years ago. Wynona has smoked cigarettes since he was a teenager and currently estimates smoking one pack of cigarettes a day.

8. [1 point] What would you expect Wynona’s Arterial Blood Gas (ABG) test results to reveal (i.e. serum pH, PCO₂, PO₂ and serum HCO₃^–)?

9. In the case of an exacerbation of her condition would providing Wynona with pure oxygen be recommended? Explain how such a pure oxygen treatment would affect her ABG values.

10. Certain long-acting Beta-adrenergic agonists used to treat COPD trigger bronchodilation by i) inhibiting myosin kinase and ii) blocking membrane Ca²⁺ channels in bronchiolar smooth muscle cells. Explain how each of these actions will promote relaxation in smooth muscle cells.