P: Population/disease ( i.e. age, gender, ethnicity, with a certain disorder)

P: _______________________________________________________________

I: Intervention or Variable of Interest (exposure to a disease, risk behavior, prognostic factor) Note: Not every question will have an intervention (as in a meaning question – see below).

I: _______________________________________________________________

C: Comparison: (could be a placebo or “business as usual” as in no disease, absence of risk factor). Note: This is not used in a meaning question – see below.

C: ______________________________________________________________

O: Outcome: (risk of disease, accuracy of a diagnosis, rate of occurrence of adverse outcome)

O: _______________________________________________________________

T: Time: The time it takes to demonstrate an outcome (e.g. the time it takes for the intervention to achieve an outcome or how long participants are observed). This is an optional “add-on” for a PICO question.

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For PICO questions about a nursing intervention/therapy:

In _______(P), what is the effect of _______(I) on ______(O) compared with _______(C) within ________ (T)?

For PICO etiology questions:

Are ____ (P) who have _______ (I) at ___ (increased/decreased) risk for/of_______ (O) compared with ______ (P) with/without ______ (C) over _____ (T)?

For PICO questions involving prevention:

For ________ (P) does the use of ______ (I) reduce the future risk of ________ (O) compared with _________ (C)?

For PICO questions that predict:

Does __________ (I) influence ________ (O) in patients who have _______ (P) over ______ (T)?

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