OH H+ CH3 H3C OH Esters can be synthesized by an acid-catalyzed nucleophilic acyl substitution between…

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OH H+ CH3 H3C OH Esters can be synthesized by an acid-catalyzed nucleophilic acyl substitution between…

OH H+ CH3 H3C OH Esters can be synthesized by an acid-catalyzed nucleophilic acyl substitution between an alcohol and a carboxylic acid; this process is called the Fischer esterification reaction. Because the alcohol oxygen is a poor nucleophile, the carbonyl carbon is made a better electrophile by protonation of the carbonyl oxygen. The steps of the synthesis are all reversible. The reaction is generally driven to completion by using an excess of the liquid alcohol as a solvent, or by distilling off the product as it forms. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions nnex :7-H O CH, H2O o CH₃ H₃
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Reference no: EM132069492

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