1. The aldol condensation reaction belongs to a group of reactions characterized by formation of an…

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1. The aldol condensation reaction belongs to a group of reactions characterized by formation of an…

1. The aldol condensation reaction belongs to a group of reactions characterized by formation of an enolate. For each of the following aldehydes or ketones, draw the enolate ion that forms when treated with a strong base such as sodium hydroxide. If an enolate cannot form, put NR (no reaction). 2. The first step in the aldol addition of acetaldehyde is an acid base reaction (proton transfer). pka = 16 pka = 15 OH a. The pk, for each acid is given. Which direction is the equilibrium favored? b. Should a much stronger base be used for this aldol addition so product is about 100% favored? Why or why not? (Hint: consider the next in the aldol addition of acetaldehyde.)
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