Write detailed, reaction mechanism of guaifensin synthesis. Must include arrows, electron flow and lone pairs.

100 Pre-lab preparation BREE In your lab notebook, prepare the following (see lab notebook guide for details): Jl. Write all procedures required for this experiment. Prepare it so that it can be used as a sole source of your experimental procedures 2. In your notebook, draw structures of both enantiomers of 3-chloro-1.2-propanediol 3. In few sentences summarize main factors that have influence on Sw2 type reactions: • the reactivity of the macleophile • the nature of the leaving group • the structure of the alkyl portion of the substrate • the nature of the solvent 4. Write detailed, reaction mechanism of guaifenesin synthesis. Must include wrows, electron flow and lone pairs. 5. Write written table of chemicals that include physicochemical data for all chemicals used (see chapter 6). 6. Write the theoretical yield calculations for this reaction. In the laboratory The essential reactants guaifenesin synthesis are provided in Table 1. Table 1. Compound 2-methoxyphenol bp (“C) Reactants used amount used mmol 550 L calculate MW 124.14 d (g/mL.) 1.13 NaOH (25% soln.) 40 1 mL b ethanol 46.07 18 water Sodium sulfate (1)-3-chloro-1,2- propanediol 142.04 110.54 1.32 500L calculate 164