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A 28-year-old male presented at his GP complaining of depression and extreme anxiety. During the appointment blood was taken for routine haematology and biochemistry analysis. The FBE was performed on a Sysmex haematology analyser, and his results were as follows:

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A 28-year-old male presented at his GP complaining of depression and extreme anxiety. During the appointment blood was taken for routine haematology and biochemistry analysis. The FBE was performed on a Sysmex haematology analyser, and his results were as follows:

RBC (x 1012/L)   WBC (x 109/L) 12.7 x 109/L
HB (g/L) 120    
HCT (L/L) 0.43 Neutrophils (x 109/L) 5.2
MCV (fL) 84 Lymphocytes (x 109/L) 5.8
MCH (pg) 25 Monocytes (x 109/L) 1.6
MCHC (g/L) 304 Eosinophils (x 109/L) 0.1
PLAT (x 109/L) 60 Basophils (x 109/L) 0
RDW (%) 12.7 total  

 

 

  1. Explain the principle and methods that the Sysmex analyser uses to determine the component of the FBE.
  2. Identify the abnormal results in this case study.
  3. Identify the conditions which cause a true thrombocytopenia and explain the possible clinical consequences for the patient.
  4. Provide a detailed overview of the common cause of pseudothrombocytopenia and propose solutions to overcome these problems.
  5. Identify the causes of true monocytosis and pseudo monocytosis and decide if this patient’s results are true. Give reasons for (justify) your decision.
  6. Referencing: Use 5-10 quality references: published research papers, scientific texts or professional websites (not sites for the general public).
  1. Length: maximum 1500 quality words excluding diagrams, tables, and the reference list.
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