A hypothetical disease is found to result from defective interleukin-3 (IL-3) signalling due to a mutation in the gene encoding the kinase JAK2. This mutation results in the production of an enzyme with only 30% of the catalytic activity of wild

A hypothetical disease is found to result from defective interleukin-3 (IL-3) signalling due to a mutation in the gene encoding the kinase JAK2. This mutation results in the production of an enzyme with only 30% of the catalytic activity of wild-type JAK2.

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